Antipsychotic Drug Fights Cancer

(Oncology Nurse Advisor) – In a prime example of finding new uses for older drugs, studies in zebrafish show that a 50-year-old antipsychotic medication called perphenazine can actively combat the cells of a difficult-to-treat form of acute lymphoblastic leukemia (ALL). The drug works by turning on a cancer-suppressing enzyme called PP2A and causes malignant tumor cells to self-destruct.

The findings suggest that developing medications that activate PP2A, while avoiding the psychotropic effects of perphenazine, could help clinicians make much-needed headway against T-cell ALL (T-ALL), and perhaps other tumors as well.

The study was led by A. Thomas Look, MD, of Dana-Farber/Boston Children’s Cancer and Blood Disorders Center, and reported the in the Journal of Clinical Investigation.

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