Clinical Trial Boasts 91% Complete Remission Rate in Children with Relapsed Leukemia

(Seattle Children’s) – Seattle Children’s announced today that 20 of 22 patients treated thus far in a clinical trial using genetically reprogrammed T cells to treat relapsed acute lymphoblastic leukemia (ALL) have achieved complete remission, confirmed by highly sensitive tests designed to detect minute amounts of cancer cells. The 20 patients who have achieved complete …

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Nanoparticles May Exploit Tumor Weaknesses to Selectively Attack Cancers

(Science Daily) – Delving into the world of the extremely small, researchers are exploring how biodegradable nanoparticles can precisely deliver anticancer drugs to attack neuroblastoma, an often-deadly children’s cancer. By bringing together experts in pediatric oncology with experts in nanotechnology, researchers at The Children’s Hospital of Philadelphia aim to thread the needle of delivering effective …

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Therapies Using Immune Engineering Show Promise for Acute Lymphoblastic Leukemia (ALL)

(Clinical Oncology News) – Two strategies that involve immune engineering have produced highly encouraging responses in acute lymphoblastic leukemia (ALL), according to data from separate studies presented at the 2014 annual meeting of the American Society of Hematology (ASH). In one study, T cells engineered for chimeric antigen receptor (CAR) targeting were used in children …

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Applying Pharmacogenomics Can Help Reduce Toxicity in Pediatric Oncology

(Pharmacy Practice News) – Because pharmacogenetic factors influence the effects of pediatric oncologic therapies, genetic information is increasingly being used to help minimize toxicities in pediatric patients with cancer, but some experts urge a cautious approach. “The goal is to identify markers of clinical, diagnostic utility that will prevent severe, adverse events in children,” said …

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Survivors of Childhood Cancer at Risk for Developing Hormone Deficiencies as Adults

(Medical Xpress) – Decades after undergoing cranial irradiation for childhood cancer, St. Jude Children’s Research Hospital investigators found that adult survivors of pediatric cancer remain at risk for pituitary hormone deficiencies that may diminish their health and quality of life. The findings appear in the February 10 edition of the Journal of Clinical Oncology. The …

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Top 10 Medical Research Issues and Trends to Watch in 2015

Our friends at FasterCures prepared this list of the top 10 medical research issues and trends to watch in 2015, first appearing in The Huffington Post. Each one of these issues impacts children with cancer. (Huffington Post) – At FasterCures, we are always thinking about ways to innovate the medical research system so that better …

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Early Progress Seen in Pediatric Immunotherapy

(Clinical Oncology News) – Heralded as a game-changer in adult oncology, immunotherapy is reshaping pediatric oncology too, but in very different ways. “Unlike our adult [oncology] colleagues who are looking at immunotherapy as possibly their only effective therapy, [in pediatrics] we’ve got an approach that we need to integrate into chemotherapy, radiation and surgery. That …

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T-Cell Therapy

T-Cell Therapy Puts Leukemia Patients in Extended Remission

(New York Times) – An experimental therapy has brought prolonged remissions to a high proportion of patients who were facing death from advanced leukemia after standard treatments had failed, researchers are reporting. The therapy involves genetically programming cells from the patient’s own immune system to fight the disease. The research included 30 patients: five adults …

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Mayo Clinic Trial: Massive Blast of Measles Vaccine Wipes Out Cancer

(Star Tribune) – Stacy Erholtz was out of conventional treatment options for blood cancer last June when she underwent an experimental trial at the Mayo Clinic that injected her with enough measles vaccine to inoculate 10 million people. The 50-year-old Pequot Lakes mother is now part of medical history. The cancer, which had spread widely …

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