

CureSearch Mission
Our mission is to end children's cancer by driving targeted and innovative research with measurable results in an accelerated time frame.
Research Vision
Improve children's cancer treatment and cures to deliver the potential for childhood cancer patients to lead long, healthy lives.

Our mission to end children’s cancer is multifaceted. It takes targeted, innovative and accelerated research to get cures developed, tested, and measured. It takes perseverance and multiple efforts to find treatments suited for young cancer fighters so that survivors live longer, healthier lives. It takes dedication from industry partners to get successful treatments and cures to the bedside of the more than 40,000 children undergoing cancer treatment right now. It takes the families, caregivers, children with cancer, the communities that support them, and people like you to keep fighting and keep hope alive. And it takes CureSearch to bring it all together.
Laura Thrall
CEO
CureSearch for Children's Cancer

As we push toward finding cures and less-toxic treatment for children with cancer, we are guided by our CureSearch core values:
HONESTY & INTEGRITY
TRANSPARENCY & ACCOUNTABILITY
CREATIVITY & COLLABORATION

![]() We focus only on children's cancer. |
![]() We're not here just to fund research, we're here to drive patient impact. |
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![]() Our Scientific Advisory Council and Scientific Review Board brain trust is unmatched. |
![]() We invest in large-scale grants over a three-year timeframe, which allows our researchers to focus on their work, not fundraising. |
![]() We hold ourselves - and our grant recipients - accountable through a novel measurement framework and frequent reporting to our constituents. |
![]() We build strong, long-term partnerships with our funded researchers so that successful work is supported beyond the scope of their original CureSearch grant. |
![]() We are bridging the 'valley of death' by creating unique partnerships with biotech and pharmaceutical industries to ensure that promising research makes it out of the lab and into the clinic. |

This $10M trailblazing initiative is our commitment to surface the most promising children's cancer research, drive it to clinical practice, and quickly find better treatments and cures.
ACCELERATION INITIATIVE 1
$5M over three years

Mary Beckerle, PhD 
Huntsman Cancer Institute
University of Utah
Epigenetics
$1.73M
2 | New drugs for Ewing sarcoma |
2 | Tumor models |
35 | Tumor samples |
"CureSearch has enabled us to perform the expensive and time-consuming phase of pre-clinical testing and helped us get closer to a clinical trial."
- Mary Beckerle, PhD
William Weiss, PhD 
The Regents of the
University of California, CA
Epigenetics
$1.88M
3 | New drugs to treat medulloblastoma |
2 | Tumor models |
28 | Tumor samples |
200 | Potential drug targets |
"Funding from CureSearch has enabled my team to test drugs that are in the clinic or about to enter trials that can be re-purposed to treat medulloblastoma."
- William Weiss, PhD
Kathleen Sakamoto, MD, PhD
Stanford University
Immunotherapy*
$1.37M
1 | Novel therapy nearing clinical trial |
1 | Pediatric trial |
7 | Tumor types tested |
"We are encouraged that with FDA approval, we can open the pediatric Phase I clinical trial by the end of 2016."
- Kathleen Sakamoto, MD, PhD
*Studies deferred.
ACCELERATION INITIATIVE 2
In partnership with Rising Tide Foundation for Clinical Cancer Research

$2M over three years
(2015-2018)
International Awards in Pediatric Cancer
AWARD 1:Targeted Research on New Approaches to Childhood Cancer Survivorship |
AWARD 2:Targeted Research on Accelerating the Delivery of New Therapies and Clinical Trial Design |
Awards will be announced October 2015

Young Investigator grants fund transformational science designed to deliver the next generation of cancer treatment. The program attracts early stage investigators and feeds the pipeline for future AI investigators.
YOUNG INVESTIGATOR 1
$1.2M over two years
(2012-2014)
Twelve researchers focused on high-risk, poor outcome cancers:
- Acute myeloid leukemia (AML)
- Adolescent and young adult tumors
- Acute lymphoblastic leukemia (ALL)
- Neuroblastoma
- Hodgkin lymphoma
- Rhabdomyosarcoma
- Late effects/survivorship
- Bone, liver, brain and renal tumors
YOUNG INVESTIGATORS
Debanjan Dhar, PhD
University of California San Diego
Hepatocellular CarcinomaDavid Gordon, MD
University of Iowa
Acute Myeloid LeukemiaEric Raabe, MD, PhD
Johns Hopkins University
Pontine Glioma (Brain Cancer)Shizhen Zhu, MD, PhD
Mayo Clinic
Neuroblastoma
YOUNG INVESTIGATOR RESEARCH MILESTONES

YOUNG INVESTIGATOR 2
$1.35M over three years
(2015-2018)*
Encouraged by the promise and success of our first 12 Young Investigators, CureSearch recently awarded six new grants. The new grant term is three years and the award has more than doubled.
Anthony Graves, MD, PhD
University of Pittsburgh
NeuroblastomaAndrew Lee Hong, MD
Dana Farber Cancer Institute
Wilms TumorRanjit Bindra, MD, PhD
Yale University
RhabdomyosarcomaAbby Rosenberg, MD, MS
Seattle Children's Hospital
Palliative Care for AYA
Birgit Knoechel, MD, PhD
Dana Farber Cancer Institute
T-cell ALL
Kara Davis, DO
Stanford University
BCP-ALL
*First progress report expected in November 2015

CureSearch has supported clinical trials in hospitals across the country for many years. In 2014, 55 hospitals received funding to support their pediatric trials. In 2015, we are offering two types of awards for local institutions:
CureSearch Community Impact Awards
Community Impact Awards |
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These Community Impact Awards will support doctors, nurses, child life specialists, social workers and other medical professionals dedicated to caring for children with cancer. Areas of focus include:
- Psychosocial Programs
- Professional Training
- Educational Resources
These CureSearch Community Impact Awards will support pilot or early phase clinical trials conducted at children’s hospitals throughout the US.
MORE INFORMATION

Because soon is not soon enough, CureSearch continues to accelerate the search for new cures. CureSearch bridges the gap between basic research discoveries and getting new cures to kids by:
INVESTING IN HIGH-IMPACT RESEARCH
- Scientists
new cures
Potential
each year
(0-19 years of age)
Children affected
FOSTERING TRANSFORMATIVE PARTNERSHIPS
- Funding collaborations with other cancer foundations including Rising Tide Foundation for Clinical Cancer Research and Gateway for Cancer Research
- Building partnerships with the pharmaceutical industry
- Facilitating relationships between academic researchers and the pharmaceutical industry partners that can translate new treatments to patient-ready drugs


In addition to driving research to end children's cancer, CureSearch is committed to supporting families and communities facing cancer today.
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Our work would not be possible without the generous support of thousands of Walkers, Hikers, Challenge-Seekers, and donors.
It is our honor to recognize the following partners for their extraordinary support:
Genentech | Love Your Melon | eBay giving works
Shark Shootout Charities | Anonymous

CureSearch is grateful to the families who have established a Champion or Legacy Fund to honor their child:
- Jacob Koenigs 'Jakefest' Memorial Fund and Kiewit
- Joey Keller Legacy Fund
- Nick Currey Fund
- Amy Miller Champion Fund
- Luke McGuire Legacy Fund
- Danielle's Roses Champion Fund
- Hammond Family Fund
- Eloise Dodge Gould Legacy Fund
The ultimate gift to support children with cancer is a bequest in your final estate plan. CureSearch is honored to be included in the final plans of these extraordinary people:
- Jean B. Michael
- Robert T. Ridley
ULTIMATE GIFTS
Honor Your Child With a Legacy or Champion Fund | Learn How to Plan the Ultimate Gift |

You want an end to children's cancer. We do too. Let's work together to raise awareness and the money it takes to find cures. Events are a great way to do both.
CureSearch offers events focused on:
Walks | Hikes |
Fitness Challenges | Kids |
Create Your Own Event |

We are shining the spotlight on children's cancer on various social media channels where we post new research developments, stories about members of our CureSearch family, videos, photos and more. Join the conversation: