(medicalxpress.com) – Pediatric oncologists from The Children’s Hospital of Philadelphia (CHOP) have reported their latest results in devising new treatments for stubbornly deadly forms of the childhood cancer neuroblastoma.
Building on their previous experiences in treating some refractory subtypes of neuroblastoma with the anticancer drug crizotinib, the researchers have identified a powerful new drug with “unparalleled” strength against forms of the cancer that resist crizotinib.
“Our preclinical results provide a strong rationale for fast-tracking this drug into clinical trials in children with neuroblastoma,” said study leader Yael P. Mossé, M.D., a pediatric oncologist at The Children’s Hospital of Philadelphia. “We expect to begin a clinical trial early this year.”
Mossé collaborated with Mark A. Lemmon, PhD, previously at the Perelman School of Medicine at the University of Pennsylvania, and currently at Yale University.
The study appeared Jan. 8 in the print edition of Cancer Discovery.