Dr. Adam Durbin, Young Investigator: Neuroblastoma
Project title: Novel agents targeting EP300-regulated transcription in neuroblastoma
Project Funded: 2019-2021
Neuroblastoma is a pediatric tumor of the peripheral sympathetic nervous system, the nerves that comprise the nervous system outside of the brain and spinal cord. Neuroblastoma impacts nearly 700 children in the US each year. Current neuroblastoma therapies contribute to a survival of only 50%. Unfortunately, even in those children that survive, treatment-induced long-term toxicities include deafness, cardiac insufficiency, infertility, and increased risk of second cancers.
Adam Durbin, MD, PhD is a CureSearch Young Investigator conducting research at the Dana-Farber Cancer Institute aiming to develop a newtargeted therapystrategy for neuroblastoma. Dr. Durbin identified a protein (EP300) that is necessary for neuroblastoma growth. Upon identification of EP300 as a druggable target, Dr. Durbin worked to develop a novel, bioavailable compound that is able to selectively destroy EP300. During the course of his CureSearch project, Dr. Durbin will investigate this new compound’s ability to stop neuroblastoma growth. If successful, this project will not only offer an innovative treatment strategy for high-risk neuroblastoma, but has the potential to expand into other EP300-dependent pediatric tumors, including myeloid leukemia and rhabdomyosarcoma.
“As both a scientist and pediatric oncologist, I am focused on developing new drugs for children with challenging-to-treat cancers,” said Dr. Durbin. “Funding from CureSearch for Children’s Cancer is critical to the early steps of our work to try to deal with these issues by developing less toxic, more effective therapies for children with cancer.”