JAMIE ANASTAS, PHD

Baylor College of Medicine

CureSearch Young Investigator Award: 2022-2025 

Focus: Pediatric High-Grade Glioma 

Project title: Combinatorial targeting of HDACs and LSD1 to treat pediatric brain tumors 

Cancer is the leading, disease-related cause of pediatric mortality in the United States, and brain tumors are among the deadliest of all childhood tumors. Outcomes for pediatric high-grade gliomas (pHGGs) range from less than 25% to essentially 0%, in the case of diffuse midline gliomas (DMGs), and these dismal survival rates have not improved in 30 years. 

Jamie Anastas, PhD, is a CureSearch Young Investigator conducting research at the Baylor College of Medicine to develop a therapy for pediatric high-grade glioma that takes advantage of a brain tumor vulnerability. Disrupted chromatin regulation is a driver of pediatric brain tumor progression, as seen in reports of promising anti-tumor activity of chromatin-targeting drugs. The studies proposed by Dr. Anastas focus on two classes of chromatin-modifying enzymes—lysine-specific demethylase 1 (LSD1) and histone deacetylases (HDACs) to develop a combination targeted therapy optimized based on molecular markers of on-target activity and a lack of toxicity. Dr. Anastas hypothesizes that combined treatment with two repurposed therapies, an LSD1 inhibitor and an HDAC inhibitor, will block pediatric brain tumor growth by altering tumor cell growth and survival and by enhancing tumor immune targeting. 

PXL_20210129_031028807.PORTRAIT_Anastas

"Pediatric high grade gliomas are notoriously resistant to conventional therapies and multi-drug, multi-model treatment regimens are likely needed to improve clinical outcomes. With support from this award from CureSearch we are excited to optimize novel combinations of chromatin-targeting drugs for the treatment of these aggressive childhood brain tumors.”
- Dr. Jamie Anastas

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