Mohamed S. Abdelbaki, MD

Mohamed Shebl Abdelbaki, MD

Washington University School of Medicine in St. Louis

Catapult Award: 2024-2027

Focus: Recurrent Brain Tumors; Natural Killer (NK) Cell Therapy

Project title: Phase I Study of Natural Killer Cells in Recurrent Malignant Brain Tumors

Dr. Mohamed Shebl Abdelbaki is the Director of both the Pediatric Neuro-Oncology Program and the Clinical Research Office (CRO) for the Pediatric Hematology, Oncology and Bone Marrow Transplant Division at St. Louis Children's Hospital. He is an Associate Professor of Pediatrics at Washington University School of Medicine in St. Louis - Missouri (USA). Dr. Abdelbaki is a member of the Central Nervous System (CNS) Committee at the Children's Oncology Group (COG), and study chair of the CNS Germinoma trial (ACNS2321). Additionally, he is the institutional Principal Investigator for both the COllaborative Network for NEuro-oncology Clinical Trials (CONNECT) consortium as well as the Pediatric Neuro-Oncology consortium (PNOC) - where he leads several clinical trials in pediatric brain tumors and also serves as a member of the scientific committee and the Chair of the Germ Cell Tumor Working Group.

Project Summary:

Dr. Mohamed Abdelbaki, a CureSearch Catapult awardee at Washington University School of Medicine in St. Louis, is conducting a phase I clinical trial using a Natural Killer (NK) cell therapy for children and young adults with recurrent brain tumors. NK cells are immune cells that can recognize and kill cancerous cells and have shown promise in treating several cancers. However, their widespread use has been limited due to production challenges and the ability of brain tumors to escape killing by secreting an immunosuppressive molecule known as transforming growth factor-beta (TGFβ). Dr. Abdelbaki and his team have established an NK cell therapy that overcomes these obstacles. They have developed a method for producing large numbers of NK cells from healthy donors and by chronically stimulating the cells with TGFβ, they have enhanced their function and made them resistant to the effects of TGFβ in the body. This ‘off-the-shelf’ cell therapy reduces the cost and eliminates barriers associated with manufacturing cells on a patient-by-patient basis, making a potentially superior treatment option more widely available to patients.

In this CureSearch-funded clinical trial, 24 children and young adults with recurrent brain tumors will receive infusions of the enhanced NK cells directly into the surgical cavity following tumor removal. This approach bypasses the blood-brain barrier and treats the tumor more effectively by concentrating the NK cells inside the tumor site. The team will also study how long the NK cells remain active in the brain and how this affects the overall response to treatment. This trial will be conducted through the Pacific Pediatric Neuro-Oncology Consortium (PNOC), making it the first multi-institutional consortium-wide study to evaluate the safety and efficacy of intra-tumoral NK cell infusions in children with recurrent brain tumors.

Research Update December 2024:

In the first 6 months of the award, Dr. Abdelbaki’s team worked diligently with PNOC to prepare for the study launch by ensuring that all necessary documents have been provided to all participating sites. The team expects that the 6 participating institutions who have successfully completed site initiation visits will open the study within the next few weeks and enroll the first patient soon after. These include UCSF, CHOP, CHLA, Washington University in St. Louis, Indiana University, and University of Alabama Birmingham. The team is continuing to work with additional PNOC sites that have expressed interest in participating to launch the trial, including international sites such as Princess Maxima (Netherlands) and IPEN Shaare Zedek (Israel).