Babak Moghimi, MD

Children with acute myeloid leukemia (AML), the second most common leukemia in children, face a poor prognosis after relapse and significant toxicity from current CAR T therapy. New treatments are critically-needed to prolong survival for these very high-risk patients. Unlike current CAR T treatment for the most common childhood leukemia, acute lymphoblastic leukemia (ALL), patients with AML experience significant toxicity with CAR T therapy. This is due, in part, to the CAR T’s target appearing on healthy cells and tumor cells, driving the therapy to attack both. Novel treatment approaches are in dire need as current AML CAR T-cells have failed to prolong survival for these very high-risk patients.

Dr. Moghimi and team at Children’s Hospital Los Angeles (CHLA) have developed next-generation AML CAR T-cells with improved precision and persistence that could be a promising tool for treating patients with relapsed/refractory AML. Dr. Moghimi's approach avoids healthy cells by targeting a combination of AML antigens, significantly increasing the accuracy and safety of the AML CAR T-cells. This novel approach could be translated into the clinic for pediatric patients at CHLA.

Research Update December 2024:

Dr. Moghimi and his team have made significant strides in refining their gated CAR T cell technology, paving the way for use in clinical trials in pediatric AML. During this reporting period, they focused on optimizing CAR T cell signaling by evaluating specific components of the signaling cascade to enhance activation and improve their effectiveness. The team also developed models that mimic patient conditions by varying levels of CD33 and CD123 antigens, enabling the study of immune escape mechanisms. Finally, they have streamlined the CAR T cell design, creating a more compact and efficient structure that simplifies packaging and enhances the potential for advanced clinical applications. These achievements represent significant progress in CAR T cell optimization and lay a solid foundation for next-generation therapies targeting pediatric AML.