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Neuroblastoma in Children

About Neuroblastoma

Sympathetic Nervous SystemNeuroblastoma is the second most common solid tumor in childhood affecting about 7% of all children with cancer. It is the most common solid cancer in infants. There are over 700 cases each year in the U.S. Neuroblastoma most often originates in the adrenal glands, which are located on top of each kidney. However, tumors can begin anywhere in the body. Other common sites are the chest, neck and pelvis. While it may be found in only one spot in the body at the time of diagnosis in some patients, in others the cancer may have spread (metastasized) from its primary location to the lymph nodes, bone marrow, or bones.

Many researchers believe that neuroblastoma develops when normal neuroblasts (the immature cells of the sympathetic nervous system) fail to mature into normal nerve cells. The sympathetic nervous system aids in the control of the body’s internal organs. The cells that make up neuroblastoma tumors are called neuroblasts. In this disease, the neuroblasts grow and divide without the usual controls, leading to the growth of a cancerous mass of cells, also called a tumor.

Signs and Symptoms of Neuroblastoma

The symptoms vary depending on the location of the tumor. Some of the more common symptoms include:

  • Abdominal swelling, pain, constipation or difficulty urinating if a tumor is present in the abdomen
  • A lump or bump in the neck that can sometimes be accompanied by drooping of the eyelid, a small pupil, and lack of sweating on the same side of the face
  • Bone pain
  • Fatigue, if the disease has spread to the bone marrow
  • Bleeding and bruising
  • Fever
  • Difficulty breathing if the tumor is present in the chest
  • Weakness or paralysis if the tumor is near the spinal cord

Less frequent symptoms caused by hormones released by the neuroblastoma cells include:

  • High blood pressure
  • Rapid heartbeat
  • Persistent diarrhea

News About Neuroblastoma

Neuroblastoma in Children was last modified: February 8th, 2017 by Geoff Duncan
Caden Shrauger, Neuroblastoma

Caden Shrauger, Neuroblastoma

3 Years Old at Diagnosis. Before Caden Shrauger could walk, he was hiking. His parents, Pam and Jason, often carried their young son in a backpack as they trekked through the mountains of Montana. The family’s healthy lifestyle also extended into the kitchen,... read more
Sadie Freifeld, Stage IV High Risk Neuroblastoma

Sadie Freifeld, Stage IV High Risk Neuroblastoma

3 Years Old at Diagnosis. “The first time, it was just complete shock and we went into autopilot mode to just fight. This time around, it hit us a little harder because I think we thought we might have actually been out of the woods after so long.” Those... read more

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