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RNA-nanoparticle vaccines for pediatric high-grade glioma

Dr. Elias Sayour – University of Florida Elias Sayour, MD, PhD

CureSearch Catapult Award: 2020-2022 

Focus: High-grade glioma  

Project Title: RNA-nanoparticle vaccines for pediatric high-grade glioma 

Project Overview: Primary high-grade gliomas (pHGGs) in children are almost uniformly lethal. While there is promise for immunotherapy, gliomas are overwhelmingly immunosuppressive, posing an access and activity challenge for the immune activation required for immunotherapy. Dr. Sayour and colleagues have developed a novel treatment platform which leverages the use of nanoparticles (NPs) combined with messenger RNA (mRNA) taken from the patient’s tumor to make a product that functions as both a vaccine and an agent that is capable of increasing activity of the immune system.  

To facilitate translation of this promising technology into first-in-human studies for pHGG, Dr. Sayour and colleagues have partnered with the Pacific Pediatric Neuro-Oncology Consortium (PNOC), where their clinical trial concept was accepted for multi-institutional trial development. Dr. Sayour anticipates opening his clinical trial for enrollment in November of 2020. 

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